Searchable abstracts of presentations at key conferences in endocrinology

ea0085oc5.1 | Oral Communications 5 | BSPED2022

Can lymphocyte subsets and B cell cytokines predict clinical response to Rituximab in paediatric graves’ disease?

Lane Laura , Wan Alana , Pearce Simon , Cheetham Tim

Background: Relapse rates in young people with GravesÂ’ disease (GD) are around 75% after 2 years of antithyroid drugs (ATD). However, there is little mechanistic insight into the pathophysiology of relapse and a lack of robust predictive biomarkers. B cell subsets and related cytokines may reflect humoral immune activity, for which T cells have an important supporting role.Aims: The purpose of this study was to evaluate T and B cell subpopulations, ...